Научные исследования

Мы не просто лаборатория, которая проводит лабораторные исследования. Мы также являемся научным центром, который ведет научные исследования и разработки новых методов диагностики. Мы проводим исследования на современном оборудовании и сотрудничаем с мировыми научными лидерами как в Украине, так и за рубежом. Средний возраст сотрудника нашей научной группы – 31 год.

Сферы наших научных интересов:



  1. Микробиом человека
  2. Генетика психиатрических, неврологических и аутоиммунных заболеваний
  3. Генетика человека
  4. Метилирование ДНК
  5. Молекулярная паразитология
  6. Разработка методов NGS диагностики
  7. Разработка биохимических методов анализа
  8. Исследование долгоживущих диких животных



Научные исследования - Лаборатория Diagen

 

Стажировка для студентов

Каждый год пятеро студентов биологических и медицинских специальностей проходят практику в лаборатории, и самые талантливые из них пополняют ряды наших сотрудников. Заявки на прохождение практики отправляйте нам на адрес [email protected]

Публикации наших сотрудников:



Научные исследования - Лаборатория Diagen

Koliada A, Moseiko V, Romanenko M, et al. Seasonal variation in gut microbiota composition: cross-sectional evidence from Ukrainian population. BMC Microbiol. 2020;20(1):100.

Vaiserman AM, Koliada AK. Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge. Hum Genomics. 2017;11(1):34.





Научные исследования - Лаборатория Diagen

Koliada A, Syzenko G, Moseiko V, et al. Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population. BMC Microbiol. 2017;17(1):120

Balistreri CR, De falco E, Bordin A, Maslova O, Koliada A, Vaiserman A. Stem cell therapy: old challenges and new solutions. Mol Biol Rep. 2020;47(4):3117–3131.

Lushchak O, Strilbytska O, Koliada A, et al. Nanodelivery of phytobioactive compounds for treating aging-associated disorders. Geroscience. 2020;42(1):117–139.

Francesco M, Arunachalam J, Banerjee A, et al. Oxidative Stress and Smoke-Related Lung Diseases: A Tentative Approach Through the Blood, Lungs, and Gut. Oxidative Stress in Lung Diseases. 2019;: 27–50.

Piskovatska V, Strilbytska O, Koliada A, et al. Health Benefits of Anti-aging Drugs. Subcell Biochem. 2019;91:339-392.

Vaiserman AM, Koliada AK, Jirtle RL. Non-genomic transmission of longevity between generations: potential mechanisms and evidence across species. Epigenetics & Chromatin. 2017; 10.

Kolyada A, Vaiserman A, Krasnenkov D, et al. Studies of Telomere Length in Patients with Parkinson’s Disease. Neuroscience and Behavioral Physiology 2016;46 (3): 344–347.

Bashinskaya V, Kulakova O, Boyko A, Favorov A, Favorova O. A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches. Human Genetics, 2015, 134:1143–1162.





Научные исследования - Лаборатория Diagen

Mamedov A, Vorobyeva N, Zakharova M, et al. Protective allele for multiple sclerosis HLA-DRB1*0101 provides kinetic discrimination of myelin and exogenous antigenic peptides. Frontiers in Immunology. 2020; 10:3088.

Kolyada A, Krasnenkov D, Vaiserman A. Telomeric Aging: Mitotic Clock or Stress Indicator? Frontiers in Genetics 2015;6.





Научные исследования - Лаборатория Diagen

Zahorodnia O, Murlanova EV, Borysovych, YH, et al. A multi-locus genetic analysis of alcohol dependence in ukrainian population. Biopolymers & Cell. 2019; 35(5): 393–393.

Borysovych Y, Murlanova EV, Zahorodnia OO, et al. Genetic risk factors of smoking status and quantity in ukrainian population. Biopolymers & Cell. 2019; 35 (5): 392-392.




Научные исследования - Лаборатория Diagen

Vaiserman A, Koliada A, Socol Y. Chapter 11 - Hormesis Through Low-Dose Radiation. Edited by Suresh I. S. Rattan and Marios Kyriazis. ScienceDirect. Academic Press. 2019;:129-138.

Vaiserman A, Koliada A, Lushchak O. Developmental programming of aging trajectory. Ageing Res Rev. 2018;47:105–122.

Vaiserman A, Koliada A, Lushchak O. Chapter 32 - Epigenetic Programming of Human Disease and Aging. Epigenetics in Human Disease (Second Edition). 2018;:975–992.

Vaiserman A, Lushchak O, Koliada A. Chapter 13 - Epigenetics of Longevity in Social Insects. Epigenetics of Aging and Longevity. 2018;:271–289.

Vaiserman A, Lushchak O, Koliada A. Chapter 13 - Epigenetics of Aging and Longevity: Translational Epigenetics. Epigenetics of Aging and Longevity. 2017;:271–285.

Lushchak O, Strilbytska O, Piskovatska V, Storey KB, Koliada A, Vaiserman A. The role of the TOR pathway in mediating the link between nutrition and longevity. Mech Ageing Dev. 2017;164:127–138.

Vaiserman AM, Koliada AK, Marotta F. Gut microbiota: A player in aging and a target for anti-aging intervention. Ageing Res Rev. 2017;35:36-45.

Vaiserman AM, Lushchak OV, Koliada AK. Anti-aging pharmacology: Promises and pitfalls. Ageing Res Rev. 2016;31:9-35.

Koliada A, Gavrilyuk K, Burdylyuk N, et al. Mating status affects Drosophila lifespan, metabolism and antioxidant system. Comp Biochem Physiol, Part A Mol Integr Physiol. 2020;

Vaiserman A, De falco E, Koliada A, Maslova O, Balistreri CR. Anti-ageing gene therapy: Not so far away? Ageing Res Rev. 2019;56.

Baulina N, Bashinskaya V, Favorova O. miRNA expression and polymorphism of miRNA genes in the myocardial infarction. Journal of Biotechnology, 2017, 256: S89.

Bashinskaya V, Favorova O. Genetics of multiple sclerosis: association analysis of GWAS-identified and microRNA-linked common genetic variations. Journal of Biotechnology, 2015. 208: S94-S95.

Osmak G, Titov B, Matveeva N, et al. Impact of 9p21.3 region and atherosclerosis-related genes`variants on long-term recurrent hard cardiac events after a myocardial infarction. Gene, 2018;647:283-288.




Научные исследования - Лаборатория Diagen

Bashynska V, Koliada A, Murlanova K, et al. Prevalence of Some Genetic Risk Factors for Nicotine Dependence in Ukraine. Genet Res Int.;2019;





Научные исследования - Лаборатория Diagen

Lushchak O, Strilbyska O, Piskovatska V, et al. Intermittent fasting. In Encyclopedia of Biomedical Gerontology. 2019;:279–290.





Научные исследования - Лаборатория Diagen

Kiselev I, Bashinskaya V, Baulina N, et al. Genetic differences between primary progressive and relapsing-remitting multiple sclerosis: The impact of immune-related genes variability. Multiple Sclerosis and Related Disorders, 2019; 29: 130-136.





Научные исследования - Лаборатория Diagen

Vaiserman A, Koliada A, Zabuga O, Socol Y. Health Impacts of Low-Dose Ionizing Radiation: Current Scientific Debates and Regulatory Issues. Dose Response. 2018;16(3)





Научные исследования - Лаборатория Diagen

Strilbytska O, Koliada A, Kenneth B, et al. Longevity and Stress Resistance Are Affected by Activation of TOR/Myc in Progenitor Cells of Drosophila Gut. Open Life Sciences 2017; 12 (1): 429–442.






Научные исследования - Лаборатория Diagen

Koliada A, Pletneva T, Sosedko A, et al. Genetic Risk Factors for Parkinson’s Disease in Ukraine. Regulatory Mechanisms in Biosystems 2015;6 (1): 45–50.





Научные исследования - Лаборатория Diagen

Kiselev I, Bashinskaya V, Kulakova O, et al.Variants of microRNA genes: gender-specific associations with multiple sclerosis risk and severity. International Journal of Molecular Sciences, 2015, 16(8): 20067-20081.





Научные исследования - Лаборатория Diagen

Bashinskaya V, Kulakova O, Kiselev I, et al.GWAS-identified multiple sclerosis risk loci involved in immune response: validation in Russians. Journal of Neuroimmunology, 2015, 282: 85–91.

Kulakova O, Tsareva E, Bashinskaya V, et al. Glatiramer acetate pharmacogenetics in Russian multiple sclerosis patients: CLEC16A and GPC5 as new players. Journal of Neuroimmunology, 2014. 275(s 1-2): 22.